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Niacinamide & Zinc PCA: Sebum Regulation & Pore Refining

September 2, 2026
•By Clinical Dermatology & Formulation Board•5 min clinical read

Formulation & Clinical Summary

Clarifying pore architecture: 5% Vitamin B3 (Niacinamide) and 1% Zinc PCA to inhibit 5-alpha reductase, reduce sebum flow, and fade post-inflammatory marks.

Niacinamide (Vitamin B3) strengthens the lipid barrier and inhibits melanosome transfer, while Zinc PCA regulates follicular sebum excretion.

1. Synergy Benefits for Oily & Congested Skin

  • Sebum Reduction: Zinc PCA inhibits 5-alpha reductase enzyme activity, decreasing excess follicular oil production by up to 45%.
  • Pore Elasticity: Niacinamide stimulates ceramide and keratin synthesis, restoring structural tone to stretched pore walls.
  • Redness Relief: Suppresses pro-inflammatory cytokines (IL-6, TNF-alpha) to calm persistent facial erythema and post-acne pigmentation.
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Clinical Dermatology & Formulation Advisory Board

Our editorial board comprises licensed cosmetic chemists, clinical dermatologists, and botanical pharmacognosy researchers auditing active concentrations, molecular delivery systems, and stratum corneum biocompatibility.

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